首頁 > 資料下載 > 金屬與顆粒物結(jié)合對(duì) 人肺上皮細(xì)胞Effects of Metals Bound to Particulate Matter on Human Lung Epithelial Cells

金屬與顆粒物結(jié)合對(duì) 人肺上皮細(xì)胞Effects of Metals Bound to Particulate Matter on Human Lung Epithelial Cells

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更新時(shí)間：2021-09-09
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吸入顆粒物與急性和慢性健康影響有關(guān)。對(duì)這些影響的關(guān)注主要來自流行病學(xué)研究，這些研究將短期內(nèi)顆粒物濃度的增加與呼吸系統(tǒng)和心血管疾病的每日發(fā)病率和死亡率的增加聯(lián)系起來。在過去的十年中，許多研究都致力于確定顆粒物與病理生理效應(yīng)之間的可能機(jī)制。雖然已經(jīng)取得了進(jìn)展，但許多關(guān)鍵方面還不清楚。因此，對(duì)可能誘發(fā)病理效應(yīng)的顆粒性質(zhì)的研究對(duì)于建立顆粒物毒性機(jī)制和產(chǎn)生必要的信息來調(diào)節(jié)產(chǎn)生毒性最強(qiáng)的顆粒的源極是至關(guān)重要的。使用實(shí)驗(yàn)室動(dòng)物進(jìn)行的研究表明，與顆粒物相關(guān)的金屬會(huì)對(duì)健康產(chǎn)生不良影響。燃煤電廠產(chǎn)生的顆粒物殘?jiān)Q為粉煤灰。煤中含有的金屬在燃燒過程中蒸發(fā)，然后在灰燼表面凝結(jié)。吸入粉煤灰可能是一種健康危害，因?yàn)榻饘購娘w灰溶解在肺細(xì)胞內(nèi)可能會(huì)引起毒性反應(yīng)。

Inhaled particulate matter has been associated with both acute and chronic health effects. Concerns about these effects derive primarily from epidemiologic studies that associate short-term increases in particle concentration with increases in daily morbidity and mortality from respiratory and cardiovascular diseases. Over the past decade much research has been directed toward identifying plausible mechanisms linking particulate matter and pathophysiologic effects. Although progress has been made, many critical aspects are not understood. Thus, studies of the properties of particles that might induce pathologic effects are critical to establishing the mechanisms of particulate matter toxicity and to producing information necessary to target regulation of the sources that generate the most toxic particles. Studies using laboratory animals have implicated metals associated with particulate matter in adverse health effects. Coal-fired power plants produce particulate residues called fly ash. Coal contains metals that vaporize during combustion and then condense on the surface of the ash. Inhaled coal fly ash could be a health hazard because metals solubilized from fly ash within lung cells may cause toxic reactions.

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