首頁 > 資料下載 > 顆粒物與基質(zhì)的協(xié)同效應上皮-間充質(zhì)轉變的硬度Synergistic Effects of Particulate Matter and Substrate

顆粒物與基質(zhì)的協(xié)同效應上皮-間充質(zhì)轉變的硬度Synergistic Effects of Particulate Matter and Substrate

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更新時間：2021-09-25
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燃燒源暴露于顆粒物（PM）與肺部炎癥和損傷有關，這會觸發(fā)修復反應以恢復正常的組織功能。隨著時間的流逝，這些反應的調(diào)節(jié)異常會導致纖維化改變，其特征是成纖維細胞和成肌纖維細胞的數(shù)量增加以及膠原蛋白和纖連蛋白在細胞外基質(zhì)中的異常沉積，從而導致基質(zhì)硬度增加和氣體交換障礙。一種理論認為成纖維細胞源自分化為間充質(zhì)細胞的肺泡上皮細胞。該過程稱為上皮-間充質(zhì)轉化（EMT）。與特發(fā)性纖維化一樣，肺部纖維化可能是進行性和致命性的，也是慢性肺部疾?。ɡ缦┑奶卣?，因此了解纖維化過程非常重要。在當前的研究中，曾獲得HEI的Walter A. Rosenblith新研究者獎的Thomas H. Barker博士及其同事對以下假設進行了檢驗：生長在纖連蛋白底物上的剛度增加的肺泡上皮細胞會經(jīng)歷EMT，并且添加精細的PM（空氣動力學直徑為PM＃2.5 m [PM2.5]）將增強這些效果。

Exposure to particulate matter (PM) from combustion sources has been associated with lung inflammation and injury, which trigger repair responses to restore normal tissue function. Dysregulation of these responses can result, over time, in fibrotic changes characterized by increased numbers of fibroblasts and myofibroblasts and abnormal deposition of collagen and fibronectin in the extracellular matrix, with consequent increases in matrix stiffness and impairment of gas exchange. One theory proposes that the fibroblasts are derived from alveolar epithelial cells that differentiate into mesenchymal cells. This process is referred to as epithelial-to-mesenchymal transition (EMT). Fibrosis in the lung can be progressive and fatal, as in idiopathic fibrosis, and is also a feature of chronic pulmonary diseases such as asthma, and it is thus important to understand profibrotic processes. In the current study Dr. Thomas H. Barker, who was a recipient of HEI’s Walter A. Rosenblith New Investigator Award, and his colleagues tested the hypotheses that alveolar epithelial cells grown on fibronectin substrates of increasing stiffness would undergo EMT and that the addition of fine PM (PM # 2.5 m in aerodynamic diameter [PM2.5]) would enhance these effects.

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