Background noise exists ubiquitously in analytical instruments, whether or not a sample is applied 
to the instrument. This document is concerned with mathematical methodologies for estimating the 
minimum detectable value in case that the most predominant source of measurement uncertainty is 
background noise. The minimum detectable value can directly and mathematically be derived from the 
stochastic characteristics of the background noise.
This document specifies basic methods to
— extract the stochastic properties of the background noise,
— use the stochastic properties to estimate the standard deviation (SD) or coefficient of variation (CV) 
of the response variable, and
— calculate the minimum detectable value based on the SD or CV obtained above.
The methods described in this document are useful for checking the detection of a certain substance 
by various types of measurement equipment in which the background noise of the instrumental 
output predominates over the other sources of measurement uncertainty. Feasible choices are visible 
and ultraviolet absorption spectrometry, atomic absorption spectrometry, atomic fluorescence 
spectrometry, luminescence spectrometry, liquid chromatography and gas chromatography.nd edition 2018-09 Capability of detection — Part 7: Methodology based on stochastic properties of instrumental noise Capacité de détection — Partie 7: Méthodologie basée sur les propriétés stochastiques du bruit instrumental Reference number ISO 11843-7:2018(E) ？ ISO 2018 ISO 11843-7:2018(E) COPYRIGHT PROTECTED DOCUMENT ？ ISO 2018 All rights reserve