The basic features of the colluvial deposit slope in Zuoyituo such as geological conditions, dimensions, slip surfaces and groundwater conditions are described concisely in this paper. The formation mechanism of the slope is discussed. It is considered that the formation of the colluvial deposit slope in Zuoyituo has undergone accumulation, slip, load, deformation and failure. The effects of rainfall on slope stability are categorized systematically based on existing methodology, and ways to determine the effects quantitatively are presented. The remained slip force method is improved by the addition of quantitative relations to the existing formulae and programs. The parameters of the colluvial deposit slope are determined through experimentation and the method of back-analysis. The safety factors of the slope are calculated with the improved remained slip force method and the Sarma method. The results show that rainfall and water level in the Yangtze River have a significant effect on the stability of the colluvial deposit slope in Zuoyituo. The hazards caused by the instability of the slope are assessed, and prevention methods are put forward.