China is facing a severe water resource crisis, and the shortage of water for agricultural consumption is a prominent problem. Irrigation with reclaimed municipal wastewater that can reach the agricultural recycling standards is an important way to deal with water shortage in agricultural production. Owing to the complex sources of municipal wastewater, there are multifarious pollutants in municipal wastewater. Improper use of wastewater can cause potential risks to ago-environment, agricultural products safety, and human health. This article deals with the current situation and the development prospects of reclaimed wastewater for agricultural use in China and abroad; the potential risks to human health and environmental pollution from the reclaimed municipal wastewater for agricultural reuse are also discussed. And some countermeasures and advices of reclaimed municipal wastewater for safety of agricultural reuse are provided.