Ralstonia solanacearum is an important model phytopathogenic bacterium that causes bacterial wilt disease on many plant species and leads to serious eco-nomic losses. The interactions between R. solanacearum and host plants have be-come a model system for the study of plants and pathogens interactions. This pa-per reviews the advances on the molecular mechanisms between R. solanacearum and hosts interaction including the formation of plant innate immunity, the suppres-sion of plant innate immunity by this pathogen and the activation of effector-trig-gered immunity. Furthermore, we made a prospect on how to utilize the interaction mechanism between R. solanacearum and hosts to control the disease.