La-doped and La-B-doped KIT-6 mesoporous materials were prepared by direct hydrothermal synthesis with pH-adjusting method and characterized by X-ray diffractometer (XRD),nitrogen sorption,FT-IR,UV-Vis,X-ray photoelectron spectroscopy (XPS) and ICP-AES.The catalytic performance for the oxidation of styrene by hydrogen peroxide,tert-butyl hydroperoxide or oxygen was investigated.The results showed that the introduction of heteroatoms did not destroy the mesostructure of KIT-6 with cubic la3d space group.La or B cations were incorporated into the framework of KIT-6 and the coexistence of B could hinder the dispersion or incorporation of La into the framework La3+ species in the framework of La-KIT-6 promoted the catalytic performance of La-KIT-6 catalyst for the oxidation of styrene.H2O2 is the better oxidant for the oxidation of styrene than ten-butyl hydroperoxide and oxygen,in which the styrene conversion of 20.6% and the selectivity to benzaldehyde of 74.6% were achieved over La-KIT-6-0.02.