The co-operation action mechanism and model of photon-ion catalysis synergy material composed of thallium and valency-variable rare earth elements and semiconductor oxide were proposed. The radiation catalysis reactions of water and oxygen assisted by the synergy material that could largely increase electron, free radical and negative ion products were discussed. The applications of photon-ion catalysis synergy material in areas of air cleaning material, antibacterial material, healthy material and energy resource material were suggested.