A newly developed model for the optimum municipal wastewater treatment plant (MWTP) design is presented. Through introducing the interval variables, the model attempts to consider the effects of uncertainties caused by the fluctuation of the wastewater quality and quantity during the design of MWTP. The model solution procedure is illustrated in detail, and a numerical example is given to verify the feasibility and advantage of the model. Furthermore, the possibility of the model application is briefly outlined.