Cobalt phthalocyanine-graphene (CoPc-Gr) complex are fabricated through π-π interaction of each components,with CoPc adsorbed/inserted on/in the graphene sheets.The obtained complex could be used in the electro-chemical detection of various medicines.CoPc-Gr modified glassy electrode shows excellent response to the electro-oxidation of dopamine (DA) and ascorbic acid (AA),much better than those of CoPc,graphene oxide (GrO) or graphene (Gr) modified electrode.Significantly,the detection of dopamine is a diffusion-controlled process,highly selective,and has a low detection limit and broad linear range.