Many zeotropic refrigerant mixtures are proposed as alternatives to some chlorofluorocarbons (CFCs) and hydrochlorofluorocarbons (HCFCs). An advantage of zeotropic mixtures is the possibility of reduction in entropy generation by matching the temperature glidings of refrigerant and heat-transfer fluid in both condenser and evaporator. Zeotropic mixtures are compared with pure refrigerants to evaluate their exergetic losses. On the other hand, the special phenomena which result from temperature gliding are proved by experiments. A simple equation is obtained, to evaluate different zeotropic mixtures' exergetic losses. The maximum flow rate of heat-transfer fluids is found in order that refrigerants phase change can be completed. Lastly, some examples of zeotropic mixtures (R407C, R405A and R414B) are given, and their exergetic losses and maximum flow rate of heat-transfer fluids in condenser are forecasted.