The poor quality of crude oil obviously leads to high sulfur contents of oil products,and the technology for desulfurization of crude oil is urgently needed so that the sulfur contents in petroleum product could be reduced from the root. This paper describes the progress in technology for desulfurization of crude oil. The present technologies for desulfurization of crude oil include caustic washing, dry gas desulfurization, hydrodesulfurization (HDS), etc.The new combined technologies for desulfurization of crude oil being studied are: biodesulfurization (BDS), hydrogenationbacterial catalysis, the microwave-catalytic hydrogenation, the BDS-OD-RA desulfurization and oxidative desulfurization in electrostatic fields, and the ultrasonic/microwave-catalytic oxidation applied in our lab, with their development trends being also discussed.