In order to evaluate cycling characters of zeotropic refrigerants in air-conditioning operation, and to reveal distribution rules of temperature difference between refrigerants and heat transfer fluids in condenser and evaporator, theoretical researches were carried out based on nonlinear relationship between temperature and enthalpy in period of refrigerants' phase change. Firstly, a phase changing model of refrigerants was built, and refrigerants state parameters were decided in the air-conditioning operation.Secondly, the state equation of refrigerants was applied for computing relationship between temperature and enthalpy, else based on some suppositions, temperature differences between 15 sorts of refrigerants and heat-transfer fluids were gotten too. Through concluding those temperature differences changing in condenser and evaporator, some rules were found. Lastly, after calculating and comparing the additive exergy loss among15 sorts of refrigerants, which resulted from the changing of temperature difference, their cycling characters evaluation were presented.